Question
Posted on: March 6 2013Best preparation method for composition: Clobetasolprop 25mg propylene glycol 25g Eucerin 25g salicylic acid 2.5 g
Propylene glycol and eucerine schiften, even after addition of Emulsify 83.
Answer
I do not think that such large amounts of propylene glycol can give a good result. I suspect the doctor forgot to provide water in the formulation. No 25 g of propylene glycol is required to dissolve 25mg of Clobetasol propionate. That is why I propose the following solution:
- in small scale clobetasolprop 25mg dissolve in 2.5 g propylene glycol
- in the same scale 25g eucerin melt at moderate heat and mix with the Clobetasolprop solution
- 22.5 g of water cooked Processed in the melted Eucerine. After preparing the CR è me 2.5 g of salicylic acid rub off with the cooled CR è me.