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Question

Posted on: March 6 2013

Can this preparation be made without the cooling ointment will lose one of its functions?

In a first preparation I moistened hydrocortisone acetate, salicylic acid and betamethasone with paraffin oil (to be easier to fit into the white petroleum jelly). Then the white petroleum jelly in the mixture of medicinal products mixed in parts. Afterwards, cold cream is mixed underneath and added up to 5% Span to glue the saponin coal tar. This preparation gave unmixing.
I replace cold cream with a more stable cetomacrogol cream and Span by Arlacel, then this preparation already gave less demixing, but the consistency of the ointment was not yet optimal. Here too, there is obviously no cooling effect anymore as the cold cream has been replaced.
can this preparation be made without the cooling ointment will lose one of its functions?
In My first preparation I made use of the thermal ointment of Conforma, in the second preparation of the Cetomacrogol cream of Pannoc.

Answer

I fear that it will be difficult to respond positively to your question. We can ask whether this cream should have a cooling effect. Adding a large amount of petroleum jelly makes this impossible. So it is important to deliver a homogeneous whole. The presence of Saponin Coaltar significantly complicates the formation of a W/O emulsion, given saponin contains Coaltar O/W emulsifiers. It is common practice to fixate saponin coaltar on starch and evaporate the alcohol present, which is already described in the question box. This mixture is then mixed with the mixture of the other powders. We rub this powder mixture with white petroleum jelly and finally with cool ointment.

Should water resign then we will have to add a small amount of Span or Arlacel. Both Span and Arlacel correspond to a sorbitanvetzuurester and are W/O emulsifiers.