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Question

Posted on: October 3 2019

Clobetasonbutyrate together with erythromycin compatible in anionic hydrophilic cream?

Prescription is as follows: Resorcinol, erythromycin, clobetasonbutyrate ad Cetomacrogol

Answer

The stability of Clobetasolbutyrate is described in the literature under   strongly   alkaline conditions. After 1 hour approximately 70% of the original concentration remained. At a pH = 8, which should be set for the stability of erythromycin (see TMF), of course, the degradation will not proceed as quickly. But one can expect a large concentration reduction after a retention period of e.g. 14 days to 1 month.    

Dissolved In water, Sulpho resorcinol gives a ph = 5; this ph approaches the ph of the buffered Cetomacrogol cream, which the TMF uses for the Cortico-esters. Therefore, Sulpho resorcinol can be processed together with clobetaspolbutyrate but not in a buffered Cetomacrogol cream (Sulpho resorcinol incompatible with Cetomacrogol) but in a buffered anionic hydrophilic cream (PH = buffered Cetomacrogol cream).  

Erythromycine Wort then delivered separately perhaps best under the form of a gel as described in the TMF.