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Question

Posted on: April 23 2013

A cloudy in my gel is created to treat mosquito bites; Can it be avoided?

I dissolve lidocaine in water and propylene glycol and hydrocortisone acetate and diphenhydramine. HCl in disinfecting alcohol. Merge the 2 solutions and stir well; Then add the HEC gel and stir well. Replenish with water to the desired amount. This gives a reasonably cloudy solution whose precipitation subsides after a time.

Answer

The question is what beats it down? This can be hydrocortisone acetate but also HEC under the influence of the high concentration of alcohol. Therefore, I would start using hydroxypropylcellulose instead of HEC as HPC is enduring high concentrations of alcohol. I would take a size glass of 100 ml and measure it in the alcohol and propylene glycol (PG). Dissolve the lidocaine and hydrocortsionacetate  . Then we add HPC and let it dissolve under regular stirring with the magnetic stirrer. Cover the beaker to avoid loss of alcohol. When the gel is formed, we add   very gradual water and look for a possible precipitation. If you see a precipitate, add an additional 10 ml PG. Add Diphenhydramine HCl and continue diluting with water   to 100 ml. Hopefully the extra 10 ml of PG is not enough extra 5 ml.