A doctor asks if it is possible to process amitryptilinehydrochloride and flupentixoldihydrochloride in a drinkable form?

1. The stability of amitriptyline hydrochloride in aqueous solution by J. Buckles, V. Walters
   

   ABSTRACT Very Little information has appeared in the literature concerning the stability of amitriptyline hydrochloride (Fig. 1) Either as the solid or in solution. The B.P. 1973 and The Extra Pharmacopoeia (1972) state that amitriptyline hydrochloride should be kept in a well closed container, but give no other storage directions either for The solid or for amitriptyline injection. However, the fact that there is a limit test for ketone and also that the injection is required to be sterilized by filtration would indicate that the solution is subject to decomposition. The present work, using thin layer chromatography and polarography, reports that solutions of amitriptyline hydrochloride in purified water at room temperature are stable for at least 8 weeks if protected from light.

2. Stability of amitriptyline hydrochloride in a commercial aqueous solution by R. Roman, E. M. Cohen, M. E. Christy, W. B. Hagerman

   ABSTRACT A commercial amitriptyline hydrochloride solution was stored at 80 ° for up to 3 Months. High-performance liquid chromatography showed no evidence of amitriptyline hydrochloride degradation. The method also indicated that two reported degradates, 3-(Propa-1.3-dienyl)-1.2:4.5-Dibenzocyclohepta-1.4-diene and Dibenzosuberone, were present at levels less than 0.1% (the detection limit of the method) under the storage conditions. The stability of the commercial solutions is attributed to their relatively low ratio of headspace oxygen to amitriptyline hydrochloride.

3. Flupenthixol dihydrochloride decomposition in aqueous solution. Enever, RP. Li Wan Po, A. Shotton, E. Dept. of Pharm., School of Pharm., Univ. of London, London, WC1N 1AX, England.

   ABSTRACT Flupentixol (Flupenthixol) dihydrochloride (I) was studied in aqueous solution in order to identify its decomposition products, to establish the degradation pathway and to examine factors of the appearance rate of the Main decomposition products. I was oxidized in the presence of air to trifluoromethylthioxanthone, ethanol (alcohols, ethyl) and piperazine via Aldehydic and Epoxidic intermediates. The formation rate of trifluoromethylthioxanthone increased with increases in pH and oxygen concentration. Buffer ions also affected the decomposition rate. Micelle formation by I protected it from oxidative decomposition.

decision
Both products are apparently very well soluble in water so that if the desired concentration permits a double extraction with warm water can be considered. Sorbitol can be dissolved In the filtrate. Many sorbitol (or sugar as in sugar syrup) reduces the oxygen content. In addition, presumably flavourings will have to be added.
in terms of stability, amitriptyline will not be the main problem but Flupenthixol appears to be less stable and prone to oxidation. The general rule is that in acidic middle oxidation is inhibited. To establish an acidic pH, vitamin C (0.2%) Perhaps most suitable as antoxidant can act together with Na2EDTA 0.1%.
An example of an analogue drink (but without vitamin C and EDTA) we find for fluoxetine:

R/Fluoxetine HCl 400mg
purified water 30g
nabenzate 100mg
Glycerol 20g
mint spiritus 1g
Sorbitol solution 70% to 100ml