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Question

Posted on: March 6 2013

A doctor asks for a nasal ointment or cream for an MRSA patient, who is allergic to many products. (OA Jew). Penicillin would be appropriate according to physician. What kind of penicillin, which

Concentration and what basis?
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Answer

If penicillin you don't have much choice considering there as raw material only potassium penicillin V is available. Perhaps you can suggest the following composition:
R/K penicillin V 20mg
liquid paraffin 5g
Vaseline 95g
First make a small amount of the Excipi ë NS in order to ensure that the base is smooth enough is for a nasal ointment. If not adjust the amount of liquid paraffin.

the base can be dry sterilized in a hot air oven at 150 ° C. The base is weighed in a beaker and covered with aluminum foil. A spatula is washed off with antiseptic solution and after drying packed in aluminum foil and with the base co-sterilized. After cooling the base and spatula, the penicillin is weighed and mixed with the sterilized base.

The ointment tubes are washed out and dried with antiseptic solution.

due to the small amount of penicillin you will be obliged to prepare 100g nasal ointment. I have failed to find stability data. So I doubt that the remaining ointment can be kept for a long time. But maybe 3 tubes can still be stored in the refrigerator. It all depends on how quickly the delivered 10g will be used up.

I also got the remark that MRSA would be resistant to penicillin (s). Maybe the doctor can consult a microbiologist?