Each gram of lipophilic Elocom cream or ointment contains 1 mg of mometasone furoate.
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Elocom 0.1% lipophilic cream has as excipients: White petroleum jelly, white beeswax, hydrogenated phosphatidylcholine, Hexyleenglycol, titanium dioxide, aluminium octenylsuccinate starch, concentrated phosphoric acid, purified water.
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Elocom lipophilic Cream is a W/O cream and is therefore to start not compatible with Nizoral cream, which is an O/W cream.
In addition, the following applies to the stability of Mometasone furoate (MF). The stability of MF decreased with increasing pH (> 4) and decreasing ionic strength in aqueous media. The chemical stability of MF in aqueous systems was significantly dependent on pH. MF appeared to be stable at pH < 4 (daarm addition of phosphoric acid) but Azure to four products at higher pH. The turnover of MF and its products appears to be catalyzed by the hydroxide ion. The pH dependence of these reactions should be considered, when Techniks or extemporaneously compounding MF formulations. An optimal pH of stability was below pH 4. The changes in pH, however, do not appear to be the only factor of importance, since an increase in ionic strength and buffer concentration displayed a stabilizing effect on this glucocorticoid in the buffers tested. Trace metal ions are unlikely to be involved in degradation of MF in aqueous solution
So this does not mean erythromycin at Elocom.
One gram Nizoral Cream contains 20 mg ketoconazole.
The full list of excipients; Propylene glycol (200mg/g) , cetyl alcohol, stearyl alcohol, sorbitanmonostearate, polysorbate 60, Polysorbate 80, sodium sulfite, Isopropylmyristaat, purified water.
In A study on the stability of ketocanazole, pH = 7 was chosen as optimal pH for a formulation in development (pH 7, 0.1% butylated hydroxytoluene). A shelf life of +/-15 months is assigned to the preparation.
Erythromycin will give a pH of +/-8. But from the published data, at pH = 8 ketoconazole is still sufficiently stable for a magisterial preparation, which has a use mine of 2 months.
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