Question
Posted on: March 6 2013Following preparation does not succeed: Clobetasone propionate 15 mg urea 3g Crotamiton 10g Menthol 300mg Petroleum Jelly Aqua + emulsify NF6 ad 100g
Answer
Solution:
in order to increase the water intake of the petroleum jelly, we will take 3 measures:
- insertion of 4g extra emulsifier and I suggest Arlacel 40 or Span 40, which has a slightly higher HLB value as Arlacel C or 83 from AVA.
- use of a small amount of Carbopol (500mg) teneide to increase the viscosity of the Crotamiton.
- reduction of the amount of water with 4.5 g
method:
weigh in a beaker Vaseline, emulsify 83 and emulsify or Span 40 and allow melting (I)
measure 30g of water, heat lightly and dissolve on the urea (II)
weigh in a Small mortar 500mg Carbopol and add the clobetasonepropion.-DILUTION and menthol; Mix and add 10g crotamiton and rub the whole to the absence of clubbers or agglomerates. III
Add the water phase (II) to the melted oil phase (I) and mix until CR è me and let stirring occasionally cool down to room temperature.
Rub (III) with the CR è me to homogeneous.
counter answer:
Preparation as specified by you indeed gives a nice CR è me.