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Question

Posted on: March 6 2013

Gelulen Omeprazole 5mg

Merck's gelules contain gastric juice-resistant granules containing 10 mg of omeprazole. The granules should be diluted with lactose to obtain sufficient volume for the gelules. Problem: The granules are very difficult to divide homogeneously over the powder which gives unevenly dosed gelules. How to fix this problem?

Answer

I do not have an elegant and correct solution to this problem which is only possible if we have similar blank granules available.

I can only come for the day with a "bad" proposal, which consists in determining the weight of 1 capsule of 10mg and then weighing half in a capsule three and bringing the remaining half back into the emptied capsule. For the remaining capsules, it may be possible to take half the weight from the Merck capsule with a fine spatte, transfer it into a capsule n ° 3 and leave the remainder in the original capsule. The client will have two types of capsules, but if you inform it, this may not be a problem.
Sorry for this monks work. Either the doctor prescribes omeprazole suspension but then we do not speak more about gastro-resistant, as you know allight.

Another and better possibility, which will then have problems at the level of the intervention by the RIZIV, consists in the use of Losec Mups 10 mg. The tablets have a partial stripe. Break the tablet into two and place a half in a soup spoon for half filled with water. Let the half-tablet completely disintegrate and apply the mixture undiluted or diluted to the child.