Question
Posted on: March 6 2013How can the very bitter taste of hydrocortisone in an oral suspension be obfuscate?
An oral suspension with hydrocortisone 1 mg/5 ml should be prepared for a 3 year old child. 50% Sirupus Simplex has already been added to the suspension medium (Xanthaamgom).
Answer
Your type of question belongs to just about the hardest thing that can be asked and this is flavor corrections.
normally, bitter flavours with another already experienced bitter taste are corrected. In the literature I have not yet found a formulation for hydrocortisone suspension. For Prednisolone. The flavouring corrigens are made using Tutti-Frutti aroma (1.4 ml per 100 ml) or from Wild cherry Aroama (2 ml per 100 ml). I also found a combination of wild cherry aroma (0.14 ml) with Nestle Quick chocolate syrup. Chocolate syrup is a bitter tasting product; This also applies to cocoa syrup (see chloramphenicolpalmitate syrup of the past). I believe that this must be the same.
a formulation, of which can go out, could look like this:
normally, bitter flavours with another already experienced bitter taste are corrected. In the literature I have not yet found a formulation for hydrocortisone suspension. For Prednisolone. The flavouring corrigens are made using Tutti-Frutti aroma (1.4 ml per 100 ml) or from Wild cherry Aroama (2 ml per 100 ml). I also found a combination of wild cherry aroma (0.14 ml) with Nestle Quick chocolate syrup. Chocolate syrup is a bitter tasting product; This also applies to cocoa syrup (see chloramphenicolpalmitate syrup of the past). I believe that this must be the same.
a formulation, of which can go out, could look like this:
hydrocortisone 20 mg
Propylene glycol 1 ml
xanthan gum 250 mg
water 25 g
Nesquick 1 soup spoon
Single syrup AD 100 ml