How do I make a solution for external use with Betamethasone dipropionate and miconazole? Betamethasone dipropionate 64mg Carbopol 0.3 g NaOH 1.5 ml after EDTA 150mg miconazole

A first remark is the lack of concentration of the NaOH solution to be used.

This is a difficult requirement, which must be thoroughly analyzed.

1. from the TMF one can learn that for the in solution keeping of 64mg Betamethasone dipropionate 70ml isopropanol is required;
2. Miconazole is "freely soluble" in isopropanol and so I suspect that Miconazole also goes into solution and remains;
3. Given this high concentration of "alcohol", a particular base is required for the neutralization of Carbopol; Given these are not available to the Officina pharmacist, I suggest using another viscosities enhancement substance;
4. replace Carbopol 0.3 g by Hydroxypropylcellulose 400 0.5 g;
5. in consequence delete 1.5 ml NaOH

As far as the method of preparation is concerned, it can broadly be used from the hydro-alcoholic solution of Betamethasone dipropionate in the TMF.