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Question

Posted on: March 6 2013

How to prepare following ear drops with Terbinafine: Terbinafine 750mg Physiologically serum 60ml ear Drops

Answer

Indeed in this concentration you will not get the Terbinafine HCl solved. To begin with, I would not use a physiological serum but glucose 5% to avoid the effect of the eponymous ion. Presumably there are possibilities to prepare a solution using cosolvents and other substances, which could increase the solubility. But we are also in the fact that we do not have the pure raw material at our disposal. I think that in these circumstances only the tablet remains to pulverize and to suspend in 5% glucose. This is not very elegant. But does the doctor disagree to make use of Lamisil Once 1% solution-for cutaneous use?