Question
Posted on: February 1 2017Is it really necessary to use the racemic mixture of amphetamine sulfate to prepare these eyedrops? Or can we also use amphetamine sulfate D?
The use of amphetamine is an alternative to Benzedrine (or hydroxyamfetamine HBr) 1% collyre (or Paredrine Collyre) Given this product is not in stock in Belgium.
According to Apoth. W. Borghys, they use in Middelheim Hospital for this indication an amphetamine Collyre:
R/Amphetamine sulfate (racemic!) 0.1 g
Boric acid 165mg
Benzalkonium chloride 1mg
Aqua purificata up to 10 ml
F. Collyre 10 ml
Answer
peculiar question there between the amphetamines, which I find in the commodity suppliers, only the racemic mixture Available. When using the D form, 75% of the prescribed dose should be used. The composition you are concerned by Apoth. Borghys must be filtered on a reinforced membrane filter 0.2 micrometer in a sterile eye dropper vial. The circumstances in which this can be performed are described in the TMF
under https://www.tmf-ftm.be/nl_NL/web/pharmacist/ftm/b/bii/bii7/bii7a)