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Question

Posted on: February 28 2018

Litican in Suppositories

I get the question of whether it is possible to prepare Litican in Suppo for a patient with severe migraines who now have to get a Litican injection every time. Alizapride is not available as raw material, so we will have to leave from crushed tablets. How does the rectal intake occur and is it necessary to have a dose adjustment?

Answer

The size of the tablets   apparently does not make a problem to use as a starting substance crushed tablets. For suppositories of 3 G you can count on 1 g solids per suppository. As for the rectal recording, I refer to:

Absolute intramuscular, oral, and rectal bioavailability of alizapride

G. Houin, J. Barre, J. P. Tillement

Abstract

A study was designed to estimate the absolute bioavailability of alizapride after intramuscular injection, oral administration as a solution or a tablet, and rectal administration as a suppository compared with that after intravenous injection. A Balanced incomplete block-design trial was adopted. The intramuscular injection and the tablet administration showed identical results with those of the intravenous injection. On the AT, the oral solution and the rectal suppository dosage forms gave lower absorption values, i.e., 75 and 61% of the dose administered was absorbed, respectively.

    A dose adjustment you will need to discuss with the doctor.