Question
Posted on: February 28 2018Litican in Suppositories
Answer
The size of the tablets apparently does not make a problem to use as a starting substance crushed tablets. For suppositories of 3 G you can count on 1 g solids per suppository. As for the rectal recording, I refer to:
Absolute intramuscular, oral, and rectal bioavailability of alizapride
G. Houin, J. Barre, J. P. Tillement
Abstract
A study was designed to estimate the absolute bioavailability of alizapride after intramuscular injection, oral administration as a solution or a tablet, and rectal administration as a suppository compared with that after intravenous injection. A Balanced incomplete block-design trial was adopted. The intramuscular injection and the tablet administration showed identical results with those of the intravenous injection. On the AT, the oral solution and the rectal suppository dosage forms gave lower absorption values, i.e., 75 and 61% of the dose administered was absorbed, respectively.
A dose adjustment you will need to discuss with the doctor.