Question
Posted on: February 14 2019A loco Actifed exhibits crystal formation when switching from sugar syrup to sorbitol non-crystallizable.
Composition: Triprolidine HCl 80 mg, codeine phosphate 400 mg, pseudoephedrine HCl 1.2 g, guaifenesin 4g, alcohol 90 ° 15 g, glycerol 10 g, water 15 g, frambozenextr 1.5 g and sugar syrup up to 200 ml
Answer
The solubility of guiafenisine in sugar syrup and in sorbitol syrup are different. In the first, solubility is 1 to 50; In the second 1 on 80. In your preparation with sugar syrup, a lot of tripolidine dissolves in sugar syrup.
Use your sorbitol then you will need to increase the amount of one of the other solvents numerally stapled alcohol 94 ° Preference (solubility 1 to 10), then glycerine comes 1 to 50.
Maybe we can make a compromise and bring the alcohol 94 ° to 20 G and the glycerin at 20 g.
Propylene glycol is also a good solvent (1 in 15) but may not be desirable anyway.