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Question

Posted on: March 6 2013

A loco-replacement of VOLUMEN?

We would like to make a preparation with locust bean gum (LBG) 0.2% and sorbitol 2% w/V. Does anyone here have experience with regard to formula, stability and any taste corrigens? Where do you order LBG?

Answer

VOLUMEN contains 0.2% LBG and 2.5% mannitol. Mannitol is distinguished from sorbitol because of its higher hygroscopic properties. I suspect that mannitol also binds more and stronger water. It is available as a raw material on the Belgian market. In contrast, LBG is not available as a registered raw material. The polymer that is closest to it is guar gum. There is only a difference in the relationship galactose to mannose. The only problem is finding the concentration, which is equivalent to 0.2% LBG. Since I suspect you have no VOLUMEN in stock I recommend you to request a sample LBG at Cargill Europe BVBA, Bedrijven Laan 9, B-2800 Mechelen, Tel: + 32 (0) 15 400 411. The producer of VOLUMEN states that the viscosity should be averaged 130 mPa. s, measured with the Brookfield device (LVF 1; 30). I think you do not possess such a device. There are two possible solutions:
  1. rely on the laboratory of Prof. De Meester (Faculty of Pharmacy, UGent) and ask that they do the measurements.
  2. measure the spout time from an eyedropper of a given volume (10 or 20 ml) solution. This method is an alternative but any alternative is less good.
In The brand product also comes BaSO4 0.1% with a particle size up to 10 micrometer. Also definitely not easy to find. But perhaps the radiologists can help themselves out of the distress via another speciality, which contains such BaSO4. In terms of stability there is no problem except for the microbiological. Because a good breeding ground will be this solution! Preservatives can also be added outside the use of freshly boiled water. It is also possible to impose a short storage and use mine. If taste improvement Is needed, you will have to appeal to the Aroma & #039; s that you can purchase.