Question
Posted on: March 6 2013A NKO doctor prescribes the following: Chloramphenicol 50 mg Urfamycine 750 mg 3 vials of Mistabron 600 mg 3 amp Celestone 1 bottle of physiological Serum AD 100 ml 8
ML per nostril DMV Rinoflow < br/> A precipitation occurs. Is this due to the low solubility of chloramphenicol in water? How to fix?
Answer
We must, of course, first look up the composition of the various specialties:
I would start by dissolving the chloramphenicol in the Celestone solution and then adding 3 ampoules of Urfamycin and Mistabron, under good mixing. If no precipitation arises, dilute this solution very slowly with physiological serum to be well attentive if a precipitate is formed. For precipitation, add 10 ml of propylene glycol, mix and verify that the formed precipitate dissolves back. If this Is the case then it can be further diluted with physiological serum with attention to precipitation formation. If there is again a precipitate then additional a small amount (5 ml) of propylene glycol can be added, depending on the volume already reached.
- Urfamycine
- contains thiamphenicol glycine HCl in Physiological serum
- Volume 3 x 5 ml = 15 ml
- Mistabron
- contains mesna dissolved in water pH = 7.5
- Volume of 3 amp = 9 ml
- Celestone
- contains betamethasone dissolved in water using propylene glycol, sorbitol and sugar. There is also citric acid and after 2 HPO 4 to buffer.
- Total Volume = 30 ml
I would start by dissolving the chloramphenicol in the Celestone solution and then adding 3 ampoules of Urfamycin and Mistabron, under good mixing. If no precipitation arises, dilute this solution very slowly with physiological serum to be well attentive if a precipitate is formed. For precipitation, add 10 ml of propylene glycol, mix and verify that the formed precipitate dissolves back. If this Is the case then it can be further diluted with physiological serum with attention to precipitation formation. If there is again a precipitate then additional a small amount (5 ml) of propylene glycol can be added, depending on the volume already reached.