Question
Posted on: January 9 2017A omeprazool (omeprazole) suspension at a reasonable cost
After all, the composition published in the TMF has not proved ideal because of the bad taste and lack of any viscosity. This is desirable to reduce the loss of a certain amount of administered volume by drooling babies.
Answer
Formula Omeprazool suspension with xanthan gum or guar gum
Omeprazool 200 mg
Water 80 ml
After bicarbonate 8.4 g
Xanthan gum 500 mg (or guar gum 1 g)
After saccharinate 100 to 200 mg
Banaaanaroma 100 mg à 200 mg (4 or 8 DR)
Sugar syrup AD 100 mL
Preparation Method
In a 150 ml beaker, apply the amount after baking soda and 80 g freshly boiled and fully cooled water together with a rudder rod and place the beaker on a magnetic stirrer until the bicarbonate is dissolved. (Dissolving bicarbonate in water is slow and therefore an important time can be made by using a Flapul 8.4% NaHCO3.)
Mix in a mortar of custom size xanthan gum with omeprazole and with after saccharin and rub this mixture with 10 g of sugar syrup and banana aroma. Add, under mix after each addition, in small amounts half From the NaHCO3 solution to itself a homogeneous clump free paste in the mortar. Dilute those paste slowly with the remaining half of the NaHCO3 solution blend under well after each addition of solution. Tarreer a reddish brown (inactinic glass) bottle (tare weight = T). Pour, under the Mortar wand with a plastic scraper, the obtained suspension in the tarred bottle. Bring on weight (100 + T) with sugar syrup. Mix until homogeneous by violently shaking the closed bottle.
The preparation with guar gum seems to be smoother
Storage and shelf life
A omeprazole suspension must be stored in the refrigerator at 4 ° C outside the influence of the light; the use mine is then 1 month
Clinical e vidence for formula with NaHCO 3 ?
Bioavailability from Omeprazole/NaHCO3 Suspension (Santarus) is shown in the figure below. The values of the plasma concentration are shown in full line. According to the study, these are similar to those obtained with the fixed dosing form. No data are available for other compounds such as Ca carbonate, which are used in certain fomulations for lowering the acidity of the stomach. The question arises as to whether the speed and degree of neutralization of gastric contents are equal to water soluble or water insoluble alcalinizing salt? Lowering the acidity of the stomach contents is necessary to limit the breakdown of omeprazole in acid center.
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Wo JM, Eversmann J, Mann S. Pharmacokinetic profile of immediate-release omeprazole in patients with gastro-oesophageal reflux associated with gastroparesis. Aliment Pharmacol Ther. 2010 Feb 15; 31 (4): 516-22.