Question
Posted on: February 21 2016A patient in our pharmacy asks for metformin HCl in solution.
Answer
I found a composition corresponding to: Metformin HCl 10 g; sugar 40 g; Kbicarbonate 500 mg; Ksorbate 120 mg; After Saccharinate 275 mg, aroma Qs; Purified water up to 100 ml
One dissolves KHCO3 and metformin HCl in 50 ml of purified water. With 1% citric acid solution is acidified to 4.6 to 5. Sugar and ksorbate are then added. Very slightly (< 30 °C) warming up may be required to solve everything. Add nasaccharinate and check the pH. If necessary, bring on 4.6 to 5. Add aroma and apply to volume. Pack in a red-brown bottle.
This composition uses KHCO3 instead of NaHCO3. KHCO3 dissolves better and faster in water and has a less unpleasant taste than NaHCO3.
This solution can be assigned a 2 month usage mine.