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Question

Posted on: February 21 2016

A patient in our pharmacy asks for metformin HCl in solution.

The same question I found on the site of Qualenica and there is referred to the American speciality Riomet. However, I wondered whether it is necessary to add potassium bicarbonate and hydrogen chloride? I thought of this formula: Metformin HCl 10gram Nasaccharinate 500 mg Bromoform Aroma 25 drops (to mask bitterness) Water AD 100 mL Is This solution stable? Is it necessary to add a buffer/preservative?

Answer

I found a composition corresponding to: Metformin HCl 10 g; sugar 40 g; Kbicarbonate 500 mg; Ksorbate 120 mg; After Saccharinate 275 mg, aroma Qs; Purified water up to 100 ml  

One dissolves KHCO3 and metformin HCl in 50 ml of purified water. With 1% citric acid solution is acidified to 4.6 to 5. Sugar and ksorbate are then added. Very slightly (< 30 °C) warming up may be required to solve everything.   Add nasaccharinate   and check the pH. If necessary, bring on 4.6 to 5. Add aroma and apply to volume.   Pack in a red-brown bottle.  

This composition uses KHCO3 instead of NaHCO3. KHCO3 dissolves better and faster in water and has a less unpleasant taste than NaHCO3.  

This solution can be assigned a 2 month usage mine.