Question
Posted on: February 21 2018Please advice on the stability of the following preparation: erythromycin 2%, metronidazole 2% Bioderma Sensibio AR 40ml
There has already been a similar question in the past regarding such cream where in that case it went to Bioderma Sensibio Forte. In the Bioderma Sensibio AR there are no carbomer and sodium PCA.
Composition Bioderma Sensibio AR:
AQUA/WAT E R/E AU, PARAFFIN LIQUIDUM/MINERAL OIL/HUILE MINERAL, GLYCERIN, TRIDECYL TRIMELLITATE, GLYCOL PALMITATE, CAPRYLIC/CAPRIC TRIGLYCERIDE, CANOLA/CANOLA OIL/HUILE DE COLZA, TRICETEARETH-4 PHOSPHAT E, FRUCTOOLIGOSACCHARIDES, MANNITOL, XYLITOL, GLYCOL STEARATE, PEG-2 STEARATE, PROPYLENE GLYCOL, GLYCYRRHETINIC ACID, PENTYLENE GLYCOL, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, 1.2-HEXANEDIOL, CAPRYLYL GLYCOL, DISODIUM EDTA, XANTHAN GUM, GLYCINE SOY (SOYBEAN) GERM EXTRACT, ALLANTOIN , LAMINARIA OCHROLEUCA EXTRACT, RHAMNOSE, GINKGO BILOBA LEAF EXTRACT, SODIUM HYDROXIDE, CAMELLIA SINENSIS LEAF EXTRACT, CITRIC ACID. [BI 527]
Answer
Acrylates/C10-C30 alkyl acrylate cross polymer is a cross linked Polyacrylicacid, which confirms to USP/NF specifications of "acrylates/C10-30 alkyl acrylate crosspolymer". so very similar to Carbomer (Carbopol).
I do not guarantee that no problems with erythromycin will occur for metronidazole it is harder to make a ruling.
The doctor will have to look for another solution if the patient should absolutely use Bioderma Sensibio AR