Preparation of Loco Redomex I.V.

The composition is reflected in the blue Compendium of AVGI

I suggest: dissolve in 5% glucose, or should yellow staining occur when storing in Isoton. Conc. of mannitol and sterilize by filtration. If multidose preparation + preservative; Company used Nipagine-Nipasol. But maybe better no multidose. See reference from the literature. A maximum shelf-life could not be found.

The stability of amitriptyline hydrochloride in aqueous solution
J. Buckles, V. Walters, School of Pharmacy, Liverpool Polytechnic, Byron St, Liverpool Li 3AF

Very Little information has appeared in the literature concerning the Stability of Amitriptyline hydrochloride (Fig. 1) either as the solid or in solution. The B.P. 1973 and The Extra Pharmacopoeia (1972) state that amitriptyline hydrochloride should be kept in a well closed container, but give no other storage directions either for The solid or for amitriptyline injection. However, the fact that there is a limit test for ketone and also that the injection is required to be sterilized by filtration would indicate that the solution is subject to decomposition. The present work, using thin layer chromatography and polarography, reports that solutions of amitriptyline hydrochloride in purified water at room temperature are stable for at least 8 weeks if protected from light.