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Question

Posted on: March 6 2013

Preparation method for cocaine 4% eye drops

We need to make cocaine 4% eye drops (10 ml), but the excipients and the quantities that we have to add are unknown to us. We do have references with cocaine and adrenaline together, but that is not the correct concentration of cocaine and the amounts of the excipients will be different without the adrenaline. We also ask about the toxicity of this collyre.

Answer

Dissolve the 4% Cocaine Hcl in a buffer solution containing per 100 ml boric acid 1.5 g; Borax 60mg; and Aqua Conservans AD 100ml. This buffer has a pH = 6.3.
4% is a common concentration.