Question
Posted on: March 18 2017At the request of a dermatologist: Clobetasol propionate in a nail polish? And in what concentration?
Answer
Clobetasolpropionate to 8% seems to give the best result
http://www.scielo.br/scielo.php?pid=S0365-05962012000200003&script=sci_arttext&tlng=pt
As Exipiens is in Belgium little choice. The first possibility is Coll Odium, the second cellulosacetophate solution.
Following possibility was found: collodion and ethanol AA 1 part. But the solubility in ethanol is only 20 mg/ml. On the other hand, Clobetasol propionate is described as soluble in acetone and DMSO. This means 33 mg to 100 mg per ml. For DMSO is specified 93 mg/ml; No value could be found for acetone. My preference goes to DMSO because this is solvent as a absorption promoter since.