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Question

Posted on: June 3 2016

Should one of the components of next preparation be overdosed based on the new rules of the TMF?

R/Xyzall 2.5 mg; Triamcinolone 4mg PF a capsule Dt 60

Answer

I am assuming that you are departing from Triamcinolone   powder in bulk. The amount of 4 mg per capsule is < 10 mg and should therefore be overdosed. The overdose of Xyzall is harder to realize as we have to assume a speciality. It is not refunded according to the rule speciality =   raw material in bulk refunded. Minister does not follow her regulations.  

you will in any case need to close the pores of the smooth mortar with the amount of filler as described in the TMF for capsules Triamcinolone 4 mg  

For the preparation of 30   capsules Triamcinolone 4 mg uses the TMF 1.5 g diluent to seal the poriiae of the smooth mortar. I would use the same quantity here for 60 capsule given the mass, which has to be inserted into the gelules, will be enlarged by the   Xyzall tablets.

So we can start to close the pores and add it according to the requirements of the TMF 252   mg triamcinolone    . Then the tablets Xyzall tablets are crushed in the mortar,   finely rubbed and blended with the mixture of triamcinolone filler in the mortar.     to finish the capsules, the amount of Filler that still needs to be added to fill the custom happiness size.