Question
Posted on: March 6 2013Stability of mouth rinse agent with Nystatin: Nilstat (100,000 ONION/ml) 30ml xylocaine 400mg Prednisolone 200mg NaCMC 2g Propylene glycol 10ml Aqua purificata AD 500ml
< br/> What is the appropriate retention period? We thought about 2 months. Should aqua Conservans be added?
Answer
In The literature it is found that Nystatin is very limited shelf life; certainly not 2 months, I would say earlier maximum 1 week when storing In the fridge. Below you will find references. The solution will need to be prepared ex tempore. It will be useful to measure the pH of the solution and if necessary set it to pH = 8. Using Aqua Conservans will not bring Earth to the dike with such a limited shelf life. Do not use freshly cooked and cooled water.
- J Pharm Biomed. 2006 SEP 26; 42 (3): 362-6.
- Pharm World Sci. 1997 Aug; 19 (4): 197-201.