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Question

Posted on: August 20 2019

Tetracycline mouthrinse Agent

We need to prepare a tetracycline 1% + lidocaine 0.5% mouthwash. How do we best start here now that disodium hydrogen phosphate is in stock breakage? Do we use best lidocaine base or HCl? Can be worked with XANTHAANGOMEXC. To get a suspension? I read that also sodium citrate can be used to obtain the desired pH. How much should be added at these percentages?

Answer

I would use the following validated Formularium composition: tetracycline HCl 1 g; Nipagine 100 mg, lidocaine 0.5 g; Nacitraat 1.3 G; Propylene glycol 1 g; Sorbitol syrup 65.5 g, xanthan gum 0.5 g and water up to 100 ml

pH 5 à 5.5

Mix in a mortar nipagine and propylene glycol, add lidocaine, rub, and mix with xanthan gum.

Dissolve in a part water Nacitraat  

Weigh in a tarred bottle 65.5 g sorbitol syrup and dissolve on tetracycline HCl  

Bring in the bottle the contents of the mortar and shake to homogenous  

Add the Nacitrate solution in order to save all tetracycline HCl  

Weigh the bottle and calculate the hoevelness of residual water

Rinse   The mortar with the remaining water and pour the rinse water into the bottle.  

Check the final weight = tare + 115   g