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Question

Posted on: February 6 2019

Tretinoin soluble in ethanol?

Answer

Tretinoine solution   3,33 g/L   Tretinoin can be in a concentration of 3,33   g/L   (or 0.413%) be dissolved in ungenerated alcohol (antiseptic solution). This solution has a density   =   0,806   g/ml. Butylhydroxytolua   (BHT) is added to this solution at a concentration of 2,67   g/L or   0.33  %.   This solution is suitable for the preparation of Alcohol-aqueous solutions and hydrogels of Tretinoîne as well as packing creams. With alcohol-poor gels and creams, a fine precipitation of Tretinoin is formed.