We are experiencing problems to get Econazol nitrate processed in the Carbopol gel.

There are three possibilities:

1. beginning to use instead of glycerin to rub use Tween 80. If the final result is good, problem solved just hole you to 2 and 3
2. you try to grind the econazol nitrate finely with a small electric coffee grinder with knives. There is a slight disadvantage and this is a possible loss of powder.
3. Econazol nitrate is soluble in methanol. Here too there is a problem. You should be able to dispose of colourless methanol. The current methanol is blue or rose coloured and after evaporating the methanol, your econazole nitrate would be stained. Not desirable;

If you can obtain the colourless lab quality then dissolve the Econazole nitrate in a small volume of methanol and pour out the solution, under good blending, on a ten G lactose powder. You must evaporate the methanol completely. You can then mix this mixture with your clobetasolbutyrate dilution and gradually mix it with Carbopolgel.