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Question

Posted on: August 23 2017

What basis do you use if chlorhexidinedigluconate is to be processed in a W/O creme?

Taking into account the incompatibility with sorbic acid and the O/W properties of chlorhexidinedigluconate 20%.

Answer

For first we should not concern ourselves with sorbic acid that can simply omit the presence of chlorhexidine.  

Any W/O cream Base We use we continue to sit with the O/W emulsifiable properties of Chlorhexidinedigluconate. These are perhaps slightly smaller in the diacetaate. But i K would suggest trying to convert the digluconate to the Water-soluble dihydrochloride that also appears as an antibacterial agent in certain pharmaceutical specialties. A small amount of NaCl (26 mg per   20mg of chlorhexidine) may already be sufficient.