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Question

Posted on: January 18 2017

What is the common concentration of adrenaline in suppositories for the treatment of hemorrhoids

Other active ingredients are Cameron 10%, prednisolone 0.1% and lidocainehcl 0.5%

Answer

These are complicated suppositories where you will have to go out of Cameron Suppositories described in the TMF.  

Usually the concentration of adrenaline is 5 à10 drops of the 1 pro thousand adrenaline or levorenine solution described in the Belgian Pharmacopoeia VI. Now this solution is little stable and mixed with the suppository mass, after a short time nothing will remain of the adrenaline. That's why we   work with adrenaline trituring in mannitol.  

a 1:200 trituring of adrenaline is suitable to replace the 1 pro thousand solution. It is best prepared on the basis of mannitol. A quantity of 10 mg trituration corresponds to 1 drop of the solution.

The preparation of a 1 to 200 trituration is not an obvious operation. Therefore, I would start the preparation of a 1 to 50 trituration

before starting, I first prepare a 1 to 10 trituration of riboflavin (tell-tale)  

then I weigh 100 mg of levorenine and add 50 mg riboflavin trituration and mix. To this mixture we add gradually according to the geometrical series 4,985   g mannitol  .  

of this trituration I take 1.250 g, add 50 mg riboflavin trituration and mix to homogeneous. Daaarna I add to this mixture 3,700   g mannitol.