Which Antioxydans for Tretinoin cream and how to prepare the cream?

The preparation of Tretinoine cream is done in three steps:

1. Hydrophilic Concentrate Base: cetostearyl alcohol 30g; Butylhydroxytolua 40mg and propylene glycol ad 100g. Gentle heating and stirring until dissolved;

    

2. Tretinoine Concentrate 2%: Tretinoin 250mg and hydrophilic concentrate base 12.25 g A small part of the hydrophilic concentrate base is brought into mortar; The necessary amount of tretinoine is attached; We mix gently and add a hydrophilic concentrate base until all the base is used up. Three times through the ointment mill. This concentrate is filled in an ointment tube and lasts for six months in the refrigerator.

    

3. Tretinoinecrème 0.05%: Tretinoin concentration 2% 1.25 g mix with 48.75 g Cetomacrogol Cream TMF Gradually blending.

It is necessary to work outside the influence of light! By carefully processing the powder in a hydrophilic matrix reduces the number of tradeoffs of tretinoin powder and the potential contact with dust particles of tretinoin. Thus, the risk of contact with Tretinoin in high concentration is mainly limited to the preparation of the concentrate. The preparation of the concentrate must be entrusted to properly qualified personnel. Women, who are in their fertility period, are excluded. Wearing gloves and a mouth mask are obligatory and the use of a dust extraction cabinet is highly recommended. When using the concentrate, women who are in their fertility period must wear gloves even if skin contact causes a quasi-negligible absorption.