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Vraag

Gepost op: 19 november 2015

Bereiding van minoxidil 5% opl met cetomacrogol 1000 en isopropanol geeft toch nog kristallisatie.

Is isopropanol ipv ethanol een mogelijke oorzaak?

Antwoord

The solubility of minoxidil in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and water was investigated in the temperature range from (278.15 to 333.15) K by a gravimetrical method. The mole fraction solubility is a function of temperature and increases with an increase of temperature. At the same temperature, the mole fraction solubility decreases in the order: methanol > 1-propanol > 1-butanol > ethanol > 2-propanol > water.  2-propanolol = isopropanol 

Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.

Dus