Bereiding van loco Redomex I.V.

De samenstelling is terug te vinden in het blauwe compendium van AVGI

Ik stel voor: oplossen in 5% glucose, of mocht geelkleuring optreden bij bewaren in isoton. conc. van mannitol en steriliseren door filtratie. Indien multidosis preparaat + bewaarmiddel; firma gebruikte nipagine-nipasol. Maar misschien beter geen multidosis. Zie referentie uit de literatuur. Een maximale houdbaarheidstermijn kon niet worden gevonden.

The stability of amitriptyline hydrochloride in aqueous solution
J. Buckles, V. Walters, School of Pharmacy, Liverpool Polytechnic, Byron St, Liverpool Li 3AF

Very little information has appeared in the literature concerning the stability of amitriptyline hydrochloride (Fig. 1) either as the solid or in solution. The B.P. 1973 and The Extra Pharmacopoeia (1972) state that amitriptyline hydrochloride should be kept in a well closed container, but give no other storage directions either for the solid or for amitriptyline injection. However, the fact that there is a limit test for ketone and also that the injection is required to be sterilized by filtration would indicate that the solution is subject to decomposition. The present work, using thin layer chromatography and polarography, reports that solutions of amitriptyline hydrochloride in purified water at room temperature are stable for at least 8 weeks if protected from light.