Question
Posted on: March 6 2013In the TMF, preparations with a corticosteroid are recommended for trituration and rightly so! But the preparation of a trituration with these micronized powders poses a lot of problems due to the
Electrostatic forces!! I think it is too simple to set: mixing with mannitol or lactose. May one be VB. Talk (1%) Mixing as anti-static to obtain a better "manipulable" powder? < br/>
Answer
There has been a lot of discussion within the Commission on the triturations. Mainly because their content is never 100% but e.g. 95.8%. This of course has its implications for the content of the preparation to which they are prepared.
to solve your problem I can advise you:
to solve your problem I can advise you:
- buy industrially prepared trituraties. I know they are there (some anyway) at Pharminova (Omega Pharma) and it was agreed that the manufacturer would indicate the content on the label. A small conversion can calculate how much is to be weighed for the final preparation.
- If you prefer to make your own triturations I would recommend you the excipient for capsule although this is no longer in conformity with the TMF! This excipient consists of SiO 2 Coll (aerosil) 0.5 g + Lactose 1aq powder 99.5 g.