Question
Posted on: November 3 2017Bad taste Solubilisaat vitamin E with Tween: what flavor?
Answer
Important remarks are not to worry about your composition. It should not be cloudy after the addition of the potassium sorbate solution. You speak of dissolve in a "part of water" and add dropwise. While I am in the preparation of vitamin A beverage in the Formularium Dutch pharmacists read "mixing with potassium sorbate solution at once". Now the clarity of the solution is not essential.
The focus is on the taste as the solution should be taken. I don't want to make you start a third time but I read that maybe banana would give a better taste.
I would therefore move away from solubilizing because it is not certain that the use of BV Cremophor EL does not give a bad taste. I read the contrary.
Perhaps we should think of the preparation of an emulsion in which we do not use a Tween 80.
I would like to suggest to you, as a starting point for your preparation , this composition, which I found in a formulary. Note the quantities of Vit E
This formula was not validated and given that the solution for the sampling should be shaken, I suspect that this emulsion is not stable. The oil phase is at the low end. We could enlarge them with 10 or 20 lml of Miglyol but would it not be better to keep it simple in order not to create any taste problems? Also is perhaps the amount of methyl cellulose not optimised. The solution must be stored in the refrigerator.
You can therefore adapt this emulsion to your prescription.
As for the taste, we have at least no Polysorbate 80! You can taste and judge whether the addition of an aroma is necessary or desirable. And what?