Question
Posted on: February 26 2018Dapsone in a cream process?
This is a specialty on the market in the USA, but we do not find the excipients of the cream back.
Is there a preferred cream base in which dapsone can be processed?
Answer
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div class = "P1" > Each gram of ACZONE Gel, 7.5%, contains 75 mg or dapsone, USP, in a gel or diethylene glycol monoethyl ether, methylparaben, acrylamide/sodium acryloyldimethyl taurate copolymer, Isohexadecane, Polysorbate 80, and purified water. div class = "P1" > div class = "P1" > Several of these ingredients are not available for the pharmacy. Given the solubility of dapsone in ethanol, it may be appropriate to try the water-free carbomb gel of the TMF. I note that in the composition of the Aczone gel a absorption promoter is used namely diethylene glycol monoethyl ether. Also this product is not available. But one might consider using 10% DMSO. P class = "P1" > P class = "P1" >