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Question

Posted on: November 3 2017

Bad taste Solubilisaat vitamin E with Tween: what flavor?

We received from a pediatrician from UZ Leuven a US for ' vitamin E oil 50mg/ml, dt 30ml, S/1ml/day '. For this we used DL-alpha-tocopheryl acetate 1.5 g, with Tween 80 as solubilisator. Following formula was used: DL-alpha-tocpherylacetate 1.5 g; Tween 80 4 G; Potassium Sorbate 90 mg; Citric acid 80 mg; Sugar syrup 4.5 g; Water AD 30ml Step 1: Tween and Vit E in bottle and swirl to mixed 2: Add sugar syrup and swirl 3: Potassium sorbate (dissolved in part of water) drip add to vial, always swirled 4: Citric acid (dissolved in other part of water) also add dropwise We have made this preparation double, and 1 version subjected to taste test: We thought it would be without flavoring, but it is absolutely NOT to take so. It gives a terribly bitter soap flavor. Raspberry aroma in different strengths: this did not mask enough Peppermint Escape Oil: We haven't tried this because it's for a baby, so not appropriate. Aniseed Escape Oil: We found a formula that uses 80mg per 30ml. This gave better results than with raspberry. But then still the aftertaste remains terrible. Baby should be 1ml per day.... Note: A solubilisate must be clear. Unfortunately, when adding potassium sorbate, it became cloudy. Also at second attempt it remained cloudy.

Answer

Important remarks are not to worry about your composition. It should not be cloudy after the addition of the potassium sorbate solution. You speak of dissolve in a "part of water" and add dropwise. While I am in the preparation of vitamin A beverage in the Formularium Dutch pharmacists read "mixing with potassium sorbate solution at once". Now the clarity of the solution is not essential.  

The focus is on the taste as the solution should be taken. I don't want to make you start a third time but I read that maybe banana would give a better taste.  

I would therefore move away from solubilizing because it is not certain that the use of BV Cremophor EL does not give a bad taste. I read the contrary.  

Perhaps we should think of the preparation of an emulsion in which we do not use a Tween 80.  

I would like to suggest to you, as a starting point for your preparation , this composition, which I found in a formulary. Note the quantities of Vit E    

Tocopherolacetat 10.0 g Methyl cellulose mV   1.0 g Glycerol 3.0 g Kaliumsorbate 0.14 g anhydrous citric acid   0.07 g purified water   ad 100.0 ml

This formula was not validated and given that the solution for the sampling should be shaken, I suspect that this emulsion is not stable. The oil phase is at the low end. We could enlarge them with 10 or 20 lml of Miglyol but would it not be better to keep it simple in order not to create any taste problems? Also   is perhaps the amount of methyl cellulose not optimised. The solution must be stored in the refrigerator.  

You can therefore adapt this emulsion to your prescription.

As for the taste, we have at least no Polysorbate 80! You can taste and judge whether the addition of an aroma is necessary or desirable. And what?