Question
Posted on: April 8 2014Cetomacrogol cream becomes quite liquid when the nystatin is added. What could be a solution?
Answer
First some important dates:
Triamcinolone acetonide maximum stability at pH =. 3.4 above pH = 5.5 rapid degradation.
Nystatin pKa = 3.62
whether there is an image-based or cetomacrogol cream will not bring drastic improvements to the common main problems:
-interaction ZnO with Nystatin
-Problem of stability of triamcinolonacetonide
If we check what happens when spécialité with the prescribed products, the combination of Triamcinolone-nystatin exists as cream but without ZnO and the combination ZnO with Nystatin is found in a base consisting of petroleum jelly.
So it seems appropriate to fall back on a water-free basis like e.g. the water-free emulsifying ointment TMF, of which I cannot guarantee that it exhibits enough flexibility to be able to be evenly spread. But a change in the ratio of Vaseline-liquid paraffin can remedy this.
The added solution Chlorhexidinedigluc. can be rubbed on the trituration of Triamcinolonacetonide.