Question
Posted on: March 19 2018Ciloxan & De-icol ear drops, solution crystallizes out after 2 nights of preservation in the Frigo.
Answer
The composition of the Icol is: dexamethasone sodium phosphate 1mg-chloramphenicol 4mg – for 1 ml and Boric acid – Sodium tetraborate 10 H 2 O-methylparahydroxybenzoate-purified water
The composition of Ciloxan is: 1 ml solution contains 3 mg ciprofloxacin (as hydrochloride); h Ulpstof with known effect: 1 ml solution contains 0.06 mg Benzalkonium chloride.
List of excipients : Benzalkonium chloride Dinatriumedetaat Mannitol Sodium acetate Acetic acid hydrochloric acid and/or sodium hydroxide (for pH setting) purified water
When the various constituents are overtaken, there are various incompatibilities dexametasone phosphate, Benzalkonium +, ciprofloxacineH +, which lead to ion pairs, which Presumably depending on their molecular weight can be water insoluble and presumably crystallize when stored in refrigerator
Therefore most likely incompatible because if the crystallization is accelerated in the fridge, it can occur in the longer term at room temperature.