To recipes helpdesk

Question

Posted on: November 9 2016

Is a conversion according to the molecular weight always necessary if the physician prescribes the base form, if the raw material is only available in the salt form?

Examples: -Hydralazine 25 mg is only available in HCl form; Should it be converted here by molecular weight? -What with chlorhexidine 0.05% in a cream? Diacetate/digluconate? Convert?

Answer

DSE situation is ambiguous. For Hibidil solution is mentioned 50mg/100 ml solution. The solution contains 50 mg chlorhexidinedigluconate per 100 ml.  

For Chlorhexidinedigluconate Cream 1% is indicated 10 mg chlorhexidinedigluconate per G and 5.3 g 20% chlorhexidinedigluconate solution is used for 100 g. The reason why more than 5 G is used is due to the fact that the concentration of the concentrated solution of chlorhexidinedigluconate   = 20% g/V. The density of this solution is > 1

Hydralazine has as mol. Gew. = 160 and hydrochloride = 196   or 196/160 = 1.0888.   If you do not change you will make 8% error. I assumed that the purity approximates 100%.

Mirror How the TMF is working for folic acid.