Question
Posted on: March 6 2013Cream that discolours and breaks down chlorhexidine 0.5% betamethasonediprop. 0.05% Cold cream (Pannoc used) ad 50g
After a few hours the ointment discolours grey and leaves water loose. After rubbing the ointment binds again. Cause and change I better from ointment base? Is there a difference between chlorhexidine acetate or gluconate?
Answer
Let us start with the last question. Whether you use the digluconate or the diacetate does not matter. With both problems. Only chlorhexidinedihdrochloride would not give a problem but the product is not offered as a pharmaceutical raw material.
to avoid discoloration, you must prepare the cool ointment yourself. Due to the presence of chlorhexidine, a preservative seems to me to be completely superfluous.
first prepare 50g of cool ointment according to the BP V and then rub the medicines with half of this CR è me into a synthetic mortar (tarred together with pestle). There is much chance that the W/O emulsion breaks. Then add 1g Arlacel and see if the CR è me is recovering. Then add residual cooling ointment to 50g.