Question
Posted on: March 14 2018A doctor in the area prescribes this complex creme. Is there a viable solution to make this creme with all the active ingredients in it?
R/Liq carb det 10%; Miconazole 2%; Lactic acid 10%; Urea 5%; Salicylic acid 1%; olive oil 20g; Glycerin 20g; Nipagine 0.5 g; After lauryl sulfate 1g; Aqua Dest AD 100g
Whether variants of this composition must be LCD dampers out?
Answer
What is striking is the absence of cetostearyl alcohol and the high total sum of the amount of medicines. Therefore, it might be consulted LCD to dry vapours so as to get the possibility to add 15 g cetostearyl alcohol.
1. Mortar of medium size (for 100 g cream) with pestle tarrating; Tare weight scoring
2. In this mortar urea finely rub and mix with salicylic acid and miconazole
3. By retract 10 g LCD Add and the alcohol evaporate using a hair dryer; once that the alcohol is evaporated Mix everything well.
4.20 g of olive oil and 15 g of cetostearyl alcohol melt at 60 ° C in large beaker
5.30 g water + 10 g lactic acid + 12 g Glycerin + 0.5 g nipagine warm up to 65 ° C; everything must be solved.
6. Water phase at oil phase and blending to emulsion; cream completely cool
7. The cream slowly quantitatively when mixing at the dry mixture (3)
8. Pan with pestle on balance roads; Total weight should be tare + 100 g if not water blending.
Should the cream still exhibit water secretion, maybe 1 to 2% methyl cellulose may be added.