Question
Posted on: March 6 2013Is The grey discoloration of a chlorhexidine-containing cream to be avoided?
In the next Cr è knife a grey discoloration was observed after a certain retention period:
R/chlorhexidine acetate 0.3 g
Prednisolone 0.3 g
Lidocaine Base 1.0 g
CETOMACROGOLCR è me ad 100g
R/Salicylic acid 0.6 gwith which Cr è mebases is chlorhexidine acetate or digluconate incompatible?
Betametasone dipropionate 18mg
chlorhexidine acetate 0.6 g
CETOMACROGOLCR è me ad 60g
Answer
Chlorhexidine salts are incompatible with buffered (possibly unbuffered) cetomacrogolcr è me TMF because of the presence of sorbic acid. This preservative should be replaced by another. If the CR è me is prepared with freshly cooked water and wrapped in a tube, given the presence of chlorhexidine, the addition of a preservative is less necessary. Shelf Life Limited to 2 months.