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Question

Posted on: March 6 2013

How can we make Coffe ï necitate ampoules to treat primary apnea in Neonati?

Answer

(Thanks Apoth. M. Dooms)

The April issue of the year 2007 of "American Journal of Health-System Pharmacy" describes the possibility for the preparation of these ampoules on the second page. We Quote:

Caffeine Citrate injection USP 60mg/3ml and Oral solution 60mg/3ml

Description Both caffeine citrate injection for intavenous administration and Caffeine Citrate oral solution are clear, odorless, sterile, non-pyrogenic , preservative-free, aqueous solution adjusted to pH 4.7. Each ml contains 20 mg caffeine citrate (equivalent to 10 mg of caffeine base) prepared in solution by the addition of 10 mfg Caffeine anhydrous to 5mg citric acid monohydrate, 8.3 mg sodium citrate dihydrate and water for injection.

Storage Store at room temperature (20-25 ° C) No data shall be provided on the shelf life period. But a shelf life of 1 year cannot be a problem.