How do I best work for: Ciclosporin 0.05% eye drops in 15 ml.

I suggest that we deliver 10 ml of the 15 ml pre-sterilized eye droplet bottles are not available.

We   Depart indeed from a Sandimmun Ampoule 250 mg per 5 ml or 50 mg/ml. The amount of ciclosporin you need in the eye drops is 5 mg.  

With a sterile syringe (I) of 10 ml, provided with a sterile   needle, we suck 1 ml from the Sandimmun ampoule (= 50 mg ciclo) and then suck out an ampoule of water for injections 9 ml of water up to the mark 10 ml.  

We mix both floats by gently shaking the syringe. Then we take a second sterile syringe (II) with sterile needle and suck 9 ml of water for injections.   We put in a pre-sterilized collyrevial 1 ml of the solution in Syringe (I) and add the 9 ml water for injections present in syringe ( II). The eyedropper vial is closed and the   content is mixed.  

For the conditions in which you can carry out this preparation, I refer you to the monograph on Artificial tears in the TMF