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Question

Posted on: March 6 2013

How do I prepare the best following preparation: Mopsoralen 150 mg (filter and extract from tablets) ungenerated alcohol AD 100 ml

Answer

Your preparation is a loco for Meladinin solution The stated amount of alcohol will not be sufficient to dissolve the 8-MOP (solubility in alcohol 95% present in the tablets): M é diBASE website The following solvents are suggested:
for a solution (weak) 0.1 g/100ml
PEG 300 (or 400), GLYCEROL and ethanol 70 °
for a solution (strong) 0.75 g/100ml
ACETONE, PROPYLENE GLYCOL and Ethanol 95 ° (solubility in acetone: 50 mg/ml)
If you want to extract all 8-MOP from the tablets then the Misshien is the simplest to use a mixture of acetone and ethanol 1:9.