Question
Posted on: September 11 2015Is it claimed that methadone HCl is less stable in solution, in the presence of raspberries syrup?
Answer
This is a very difficult question to answer. An answer to this question is not to be found in the literature; Both syrups are very complex mixtures and which researcher will be interested in this.
Without speaking about the difference of ingredients between the natural and the artificial syrup, a possible difference in pH is still mentioned.
Now in the presence of citric acid as foreseen in the composition of the TMF, I do not think that the pH can be much more acidic. All you can do is check if there is a noticeable difference in pH measurable.
I would also like to remind you of the recommended composition published in the TMF. This makes use of banana aroma, which I believe is a raw material reimbursable by the RIZIV.
I have not been able to findorange peel or orange blossom as aroma for methadone. Lemon or lime spiritus 2%