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Question

Posted on: March 29 2018

In the list of Max doses, chloropheniraminemaleate is not included but Dexchlorpheniraminemaleate does. What do I do

Is it best to take into account the maximum dose of the chloropheniraminemaleate isomer or can only equate with salt forms?

Answer

Bassron has recently deleted dexchlorpheniramine maleate (CNK 0321067) from its range.   The best alternative we can offer you is Chlorpheniramine maleate. (= Chlorphenamine maleate).   Dexchlorpheniramine Maleate is the right-rotating isomer (the D-form) of Chlorpheniramine maleate.   Chlorpheniramine Maleate is the racemic mixture and contains 50% D-form and 50% L-form (this latter form is inactive). Hence, the necessary dose of chlorpheniramine maleate is twice as high as Dexchlorpheniramine maleate for the same activity (Martindale).