A modified method for the preparation of a hydrophilic Tretinoin concentrate 2%.

Tretinoin can be found in the article "The processing of hazardous substances in the Officina". This article elaborately discusses the side effects and toxicity of this product. Due to the fact that Tretinoin is not available as a micronized powder, an intensive crushing is necessary. Dust formation is inevitable. For this reason, other possibilities were sought to obtain a very fine product. The article prefers to follow the method of the German formulary. This method was previously placed on the website under the question ' which antioxydance for Tretinoin cream and how to prepare the cream? '

Therefore, the preparation of a fixed dilution is also advisable! I would suggest 50 mg of tretinoin to be processed in 2450mg hydrophilic concentrate base. Or even better: use 100mg Of tretinoin and 4.5 g concentrate base.