Nasal drops Prepare Mometasone 10 ml, Nesivine 10ml and physiologically water 20 ml how to prepare?

Composition Nesivine:  

The active substance is oxymetazoline hydrochloride: 0.5 mg/ml. The other ingredients are citric acid monohydrate, sodium citrate, glycerol, benzalkonium chloride, purified water.  

Compound Mometasone  

-the active substance in this medicine is mometasonfuroate. Each time you activate the pump, a measured dose of 50 microgram mometasone furoate (as Mometasonfuroate monohydrate) is issued. -The other ingredients are microcrystalline cellulose and sodium carmellose, glycerol, citric acid monohydrate, sodium citrate dihydrate, Polysorbate 80, Benzalkonium chloride, water for injections.  

Mometasone is a suspension with a viscosite booster Avicel RC 591, consisting of microcrystalline cellulose and NaCMC. When you dilute Mometasone with Nesivine you will get the interaction between Oxymetazoline + and CMC-. This interaction is visible by flakes of CMC and the emergence of clubbers in the medium. This flocculation will be further strengthened by the influence of NaCl, present in physiological serum.  

The solution lies in its own preparation of a loco Mometasone On the basis of another thickening agent like e.g. methyl cellulose.   After all, Mometasonfuroate is available as a raw material. This is not impossible but not easy. A tailor made composition I do not know described.   But I suggest you do the following for  

of mometasonfuroate you need 5 mg for, a quantity that is not tradeable. I count for the loco momethasone 0.5% methyl cellulose this is +/-50   mg methyl cellulose.         If we now weigh 50 mg mometasone and mix with 450 mg methyl cellulose and weigh this mixture 50 mg then we have 5 mg mometasone and 45 MG methyl cellulose.  

On the other hand, we prepare a solution with NaH2PO4.2 AQ 150   MG, Na2HPO 4.12 aq 200 mg, NaCl 4.25   g,   Benzalkonium chloride 50 mg and water up to 500 ml

with 10 ml of this solution   and 50 mg of the mixture Mometasonfuroate-methyl cellulose is a suspension prepared.   Moisten The powder mixture first with a few drops of Tween 80 and rub this mass with medium, which is warmed up to +/-70 ° C. When cooling down, the methyl cellulose will gradually dissolve and swell.  

with this you can then the Nesivine nasal drops and the physiologically Add serum.